Objective: To observe the effect of coarse cereals on improving the disorder of lipid metabolism and the expression of PPARgamma mRNA in white adipose tissue in rats to investigate the mechanism of coarse cereals on lipid metabolism disorder.
Methods: Forty four SPF rats were randomly divided into 4 groups: the negative control group was fed with normal diet and 3 experimental groups were fed with high-fat modeling diet for 6 weeks for model building. The 3 experimental groups, the coarse cereals group,rice-flour group and the hyperlipemia model group, were then fed with coarse cereals high-fat diet,rice-flour high-diet and high-fat modeling diet respectively for another 15 weeks.
Results: Compared with the hyperlipemia modeling group, serum TG, TC, IL-6 and TNF-alpha in the coarse cereals group were declined significantly (P < 0.05), serum HDL-C in coarse cereals group was higher than that in rice-flour group and hyperlipemia model group (P < 0.05), LPL, HL and TNF-alpha in coarse cereal group were close to the negative control group. Moreover, the expression of PPAR-gamma mRNA in white adipose tissue of the coarse cereals group was higher than other groups.
Conclusion: The coarse cereals could activate PPARgamma and enhance the activity of key enzymes in lipids metabolism, so as to reduce the level of TG relieve inflammation and improve lipid dysmetabolism eventually.