Abstract
A drimane, (+)-drimenol (1), five known herbertanes, (-)-alpha-herbertenol (2), (-)-herbertenediol (3), mastigophorene A (4), (-)-mastigophorene C (5) and (-)-mastigophorene D (6), a pimarane, (-)-ent-pimara-8(14),15-dien-19-oic acid (7), and two eudesmanolides, (-)-diplophyllolide A (8) and (-)-diplophyllin (9) were isolated from the Tahitian Mastigophora diclados (Brid.) Nees. Herbertane sesquiterpenes (2, 3, 5 and 6) showed cytotoxicity against HL-60 and KB cell lines, radical scavenging activity and antimicrobial activity against Bacillus subtilis. (-)-Diplophyllolide A (8) also exhibited cytotoxicity against HL-60 and KB cell lines.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Infective Agents / chemistry
-
Anti-Infective Agents / isolation & purification*
-
Anti-Infective Agents / toxicity
-
Cytotoxins / chemistry
-
Cytotoxins / isolation & purification*
-
Cytotoxins / toxicity
-
Free Radical Scavengers / chemistry
-
Free Radical Scavengers / isolation & purification*
-
Free Radical Scavengers / toxicity
-
HL-60 Cells
-
Hepatophyta* / chemistry
-
Hepatophyta* / toxicity
-
Humans
-
KB Cells
-
Plant Extracts / chemistry
-
Plant Extracts / isolation & purification
-
Plant Extracts / toxicity
-
Polynesia
-
Sesquiterpenes / chemistry
-
Sesquiterpenes / isolation & purification*
-
Sesquiterpenes / toxicity
Substances
-
Anti-Infective Agents
-
Cytotoxins
-
Free Radical Scavengers
-
Plant Extracts
-
Sesquiterpenes