Abstract
Cocaine addiction has somatic, psychological, psychiatric, socio-economic and legal implications in the developed world. Presently, there is no medication approved for the treatment of cocaine addiction. In recent years, data from the literature (pre-clinical studies and clinical trials) have provided several lines of evidence that serotonin (5-HT) and 5-HT receptors play a modulatory role in the mechanisms of action of cocaine. Here we review the contribution of 5-HT receptor subtypes to cocaine sensitization, discrimination, conditioned place preference, self-administration, reinstatement of seeking behavior and withdrawal symptoms in laboratory animals. Additionally, the consequences of chronic cocaine exposure on particular 5-HT receptor-assigned functions in pre-clinical studies are presented.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Appetitive Behavior / drug effects
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Appetitive Behavior / physiology
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Association Learning / drug effects
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Association Learning / physiology
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Brain / drug effects*
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Brain / physiopathology*
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Cocaine / administration & dosage
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Cocaine / toxicity
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Cocaine-Related Disorders / physiopathology*
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Conditioning, Classical / drug effects
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Conditioning, Classical / physiology
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Consummatory Behavior / drug effects
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Consummatory Behavior / physiology
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Discrimination, Psychological / drug effects
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Discrimination, Psychological / physiology
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Disease Models, Animal
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Dopamine / physiology
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Dopamine Plasma Membrane Transport Proteins / antagonists & inhibitors
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Dopamine Plasma Membrane Transport Proteins / physiology
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Dopamine Uptake Inhibitors / administration & dosage
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Dopamine Uptake Inhibitors / toxicity
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Dose-Response Relationship, Drug
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Emotions / drug effects
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Emotions / physiology
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Euphoria / drug effects
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Euphoria / physiology
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Humans
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Motivation
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Norepinephrine Plasma Membrane Transport Proteins / antagonists & inhibitors
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Norepinephrine Plasma Membrane Transport Proteins / physiology
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Rats
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Receptors, Serotonin / drug effects*
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Receptors, Serotonin / physiology*
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Self Administration
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Substance Withdrawal Syndrome / physiopathology
Substances
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Dopamine Plasma Membrane Transport Proteins
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Dopamine Uptake Inhibitors
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Norepinephrine Plasma Membrane Transport Proteins
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Receptors, Serotonin
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Cocaine
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Dopamine