A functionalized gold nanoparticles-assisted universal carrier for antisense DNA

Chem Commun (Camb). 2010 Jun 21;46(23):4151-3. doi: 10.1039/c0cc00103a. Epub 2010 May 10.

Abstract

In this study, single-stranded DNA functionalized gold nanoparticles (AuNP GDS) were proved to be efficient gene delivery systems for oligo antisense DNAs specific to any gene of interest without affecting normal cell physiology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA, Antisense / administration & dosage*
  • DNA, Antisense / genetics
  • DNA, Single-Stranded / chemistry*
  • Gene Knockdown Techniques
  • Gene Transfer Techniques*
  • Genes, p53
  • Gold / chemistry*
  • HeLa Cells
  • Humans
  • Nanoparticles / chemistry*

Substances

  • DNA, Antisense
  • DNA, Single-Stranded
  • Gold