Abstract
Throwing tumors a left hook punch: The oncoprotein MDM2 negatively regulates the activity and stability of the tumor suppressor protein p53, and is an important molecular target for anticancer therapy. Mirror image phage display identifies a high-affinity D-peptide ligand of MDM2 that can be developed into a potent and protease-resistant p53 activator with potential antitumor activity.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Drug Design
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Enzyme Inhibitors / chemistry
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Humans
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Ligands
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Molecular Sequence Data
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Peptides / chemistry
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Peptides / genetics
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Peptides / pharmacology*
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Proto-Oncogene Proteins c-mdm2 / antagonists & inhibitors*
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Proto-Oncogene Proteins c-mdm2 / chemistry
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Stereoisomerism
Substances
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Enzyme Inhibitors
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Ligands
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Peptides
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MDM2 protein, human
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Proto-Oncogene Proteins c-mdm2