Design of fluorescently tagged poly(alkyl cyanoacrylate) nanoparticles for human brain endothelial cell imaging

Chem Commun (Camb). 2010 Apr 21;46(15):2602-4. doi: 10.1039/b924028d. Epub 2010 Feb 4.

Abstract

Rhodamine B-tagged poly(alkyl cyanoacrylate) amphiphilic copolymers have been synthesised, characterised and successfully used to prepare fluorescent nanoparticles for human brain endothelial cell imaging, allowing their uptake and intracellular trafficking to be finely observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / cytology
  • Cell Line
  • Cyanoacrylates / chemistry*
  • Endothelial Cells / cytology*
  • Fluorescent Dyes / chemistry*
  • Humans
  • Microscopy, Confocal
  • Nanoparticles / chemistry*
  • Particle Size
  • Polymers / chemical synthesis
  • Polymers / chemistry*
  • Rhodamines / chemistry

Substances

  • Cyanoacrylates
  • Fluorescent Dyes
  • Polymers
  • Rhodamines
  • rhodamine B