Dextran based pH-activated near-infrared fluorescence nanoprobe imaging the acidic compartments in cancer cells

Chem Commun (Camb). 2010 Feb 28;46(8):1326-8. doi: 10.1039/b917368d. Epub 2010 Jan 11.

Abstract

A novel dextran-based nanoprobe was synthesized and demonstrated the pH-activated near-infrared (NIR) fluorescence in the physiologically acidic aqueous solutions and acidic compartments in human glioblastoma cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cell Survival
  • Dextrans / chemical synthesis
  • Dextrans / chemistry*
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • Glioblastoma / diagnosis*
  • Humans
  • Hydrogen-Ion Concentration
  • Spectroscopy, Near-Infrared / methods*

Substances

  • Dextrans
  • Fluorescent Dyes