Affinity measured by microcluster

J Exp Med. 2010 May 10;207(5):907-9. doi: 10.1084/jem.20100780. Epub 2010 May 3.

Abstract

Like T cell activation, B cell activation is driven by aggregation of B cell receptors (BCRs) into microclusters. New work suggests that the early dynamics of BCR mobility and microcluster formation "translate" BCR affinity for antigen into B cell responsiveness.

Publication types

  • Comment

MeSH terms

  • Actins / immunology
  • Animals
  • B-Lymphocytes / immunology
  • Cytoskeletal Proteins / immunology
  • Genetic Engineering
  • Immunological Synapses / immunology
  • Lymphocyte Activation / immunology
  • Mice
  • Models, Immunological
  • Receptors, Antigen, B-Cell / immunology*
  • Signal Transduction / immunology
  • T-Lymphocytes / immunology

Substances

  • Actins
  • Cytoskeletal Proteins
  • Receptors, Antigen, B-Cell
  • ezrin