Abstract
Like T cell activation, B cell activation is driven by aggregation of B cell receptors (BCRs) into microclusters. New work suggests that the early dynamics of BCR mobility and microcluster formation "translate" BCR affinity for antigen into B cell responsiveness.
MeSH terms
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Actins / immunology
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Animals
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B-Lymphocytes / immunology
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Cytoskeletal Proteins / immunology
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Genetic Engineering
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Immunological Synapses / immunology
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Lymphocyte Activation / immunology
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Mice
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Models, Immunological
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Receptors, Antigen, B-Cell / immunology*
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Signal Transduction / immunology
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T-Lymphocytes / immunology
Substances
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Actins
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Cytoskeletal Proteins
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Receptors, Antigen, B-Cell
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ezrin