Regulation of RNA polymerase II elongation by c-Myc

David H Price

doi:10.1016/j.cell.2010.04.016

Regulation of RNA polymerase II elongation by c-Myc

Cell. 2010 Apr 30;141(3):399-400. doi: 10.1016/j.cell.2010.04.016.

Author

David H Price¹

Affiliation

¹ Biochemistry Department, University of Iowa, Iowa City, IA 52242, USA. david-price@uiowa.edu

PMID: 20434979
DOI: 10.1016/j.cell.2010.04.016

Abstract

The genome-wide mapping presented in this issue by Rahl et al. (2010) demonstrates how the transcription factor c-Myc interfaces with the machinery that controls RNA polymerase II elongation. These findings account for the ability of c-Myc to activate the expression of a large number of genes that promote rapid proliferation.

Publication types

Comment

Grants and funding

R33 AI074392/AI/NIAID NIH HHS/United States