Tetherin: holding on and letting go

Daniel Sauter; Anke Specht; Frank Kirchhoff

doi:10.1016/j.cell.2010.04.022

Tetherin: holding on and letting go

Cell. 2010 Apr 30;141(3):392-8. doi: 10.1016/j.cell.2010.04.022.

Authors

Daniel Sauter¹, Anke Specht, Frank Kirchhoff

Affiliation

¹ Institute of Molecular Virology, University Clinic Ulm, Meyerhofstrasse 1, 89081 Ulm, Germany.

PMID: 20434978
DOI: 10.1016/j.cell.2010.04.022

Abstract

Mammalian cells are equipped with so-called "restriction factors" that suppress virus replication and help to prevent virus transmission from one species to another. This Essay discusses the host restriction factor tetherin, which blocks the release of enveloped viruses like HIV-1, and the factors evolved by primate lentiviruses, such as Vpu and Nef, that antagonize tetherin's action.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antigens, CD / genetics
Antigens, CD / immunology
Antigens, CD / metabolism*
GPI-Linked Proteins
Gene Products, nef / metabolism
HIV-1 / metabolism*
Human Immunodeficiency Virus Proteins / metabolism
Humans
Lentivirus / genetics
Lentivirus Infections / drug therapy
Membrane Glycoproteins / genetics
Membrane Glycoproteins / immunology
Membrane Glycoproteins / metabolism*
Viral Regulatory and Accessory Proteins / metabolism

Substances

Antigens, CD
BST2 protein, human
GPI-Linked Proteins
Gene Products, nef
Human Immunodeficiency Virus Proteins
Membrane Glycoproteins
Viral Regulatory and Accessory Proteins
vpu protein, Human immunodeficiency virus 1