A chromone from Seseli praecox (Apiaceae)

Nat Prod Commun. 2010 Apr;5(4):551-4.

Abstract

Chemical investigation of the stems of Seseli praecox (Gamisans) Gamisans, an endemic Apiaceae from Sardinia, afforded an isopropenylated chromone (5-hydroxy-6-(2-Z-butenyl-3-hydroxymethyl)-7-methoxy-2-methylchromone), along with four known linear furocoumarins and their natural precursor. For biological characterization the new compound was screened against four cancer cell lines in vitro and showed differential microM antiproliferative effects between suspension and adherent cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Apiaceae / chemistry*
  • Cell Survival / drug effects
  • Chromatography, High Pressure Liquid
  • Chromones / chemistry
  • Chromones / isolation & purification*
  • Chromones / pharmacology
  • HL-60 Cells
  • Humans
  • Inhibitory Concentration 50
  • Jurkat Cells
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Stems / chemistry
  • Spectrometry, Mass, Electrospray Ionization

Substances

  • Antineoplastic Agents
  • Chromones