Ceramide-mediated transport of chloride and bicarbonate across phospholipid membranes

Chem Commun (Camb). 2010 Jun 14;46(22):3950-2. doi: 10.1039/c0cc00493f. Epub 2010 Apr 29.

Abstract

The sphingolipid, ceramide 1, facilitates transport of Cl(-) and HCO(3)(-) anions across lipid bilayers under conditions where large transmembrane pores are not formed. Ceramide's 1,3-diol unit is essential for both binding and transporting these anions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Bicarbonates / metabolism*
  • Biological Transport
  • Ceramides / chemistry*
  • Ceramides / metabolism
  • Chlorides / metabolism*
  • Lipid Bilayers / chemistry*

Substances

  • Bicarbonates
  • Ceramides
  • Chlorides
  • Lipid Bilayers