Automation in the high-throughput selection of random combinatorial libraries--different approaches for select applications

Jörn Glökler; Tatjana Schütze; Zoltán Konthur

doi:10.3390/molecules15042478

Automation in the high-throughput selection of random combinatorial libraries--different approaches for select applications

Molecules. 2010 Apr 8;15(4):2478-90. doi: 10.3390/molecules15042478.

Authors

Jörn Glökler¹, Tatjana Schütze, Zoltán Konthur

Affiliation

¹ Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr. 63-73, Berlin, Germany. gloekler@molgen.mpg.de

Abstract

Automation in combination with high throughput screening methods has revolutionised molecular biology in the last two decades. Today, many combinatorial libraries as well as several systems for automation are available. Depending on scope, budget and time, a different combination of library and experimental handling might be most effective. In this review we will discuss several concepts of combinatorial libraries and provide information as what to expect from these depending on the given context.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Automation, Laboratory*
Combinatorial Chemistry Techniques*
High-Throughput Screening Assays*
Peptide Library*
Robotics*
SELEX Aptamer Technique
Small Molecule Libraries / chemistry*

Substances

Peptide Library
Small Molecule Libraries