Abstract
This study reports two novel 5-fluorouracil-substituted ampelopsin derivatives. The structures of two new derivatives were characterized by elemental analysis, 1H-NMR, 13C-NMR, IR and MS. Their anticancer activities in vitro against two cancer cell lines, K562 and K562/ADR, were investigated using the MTT assay, and the results showed that the two new compounds were more effective than reference drugs such as ampelopsin and verapamil.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Flavanones / chemical synthesis*
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Flavanones / chemistry
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Flavanones / pharmacology
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Flavonoids / chemical synthesis*
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Flavonoids / chemistry*
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Flavonoids / pharmacology
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Fluorouracil / analogs & derivatives*
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Fluorouracil / chemical synthesis
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Fluorouracil / chemistry*
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Fluorouracil / pharmacology
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Humans
Substances
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2-(4-(2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetoxy)-3,5-dihydroxyphenyl)-5,7-dihydroxy-4-oxochroman-3-yl-2-(5-fluoro-2-dihydropyrimidin-1(2H)-yl)acetate
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5,7-dihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)chroman-3-yl-2-(5-fluoro-2,4-dioxo-3,4-dihydroxypyrimidin-1(2H)-yl)acetate
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Antineoplastic Agents
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Flavanones
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Flavonoids
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ampelopsin
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Fluorouracil