Enzymatically triggered amyloid formation: an approach for studying peptide aggregation

Chem Commun (Camb). 2010 May 14;46(18):3080-2. doi: 10.1039/c001460e. Epub 2010 Mar 30.

Abstract

A strategy has been demonstrated that utilizes a phosphatase as a natural tool for the triggering and control of amyloid formation in a coiled coil peptide model under conditions that closely approximate a physiological environment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Amyloid / metabolism*
  • Circular Dichroism
  • Models, Biological
  • Molecular Sequence Data
  • Peptides / chemistry
  • Peptides / metabolism*
  • Phosphates / metabolism*
  • Protein Conformation
  • Protein Folding

Substances

  • Amyloid
  • Peptides
  • Phosphates