Abstract
A strain-induced copper-free click reaction mediated by a new and easily prepared cyclooctyne derivative was used to efficiently assemble a DOTA-biotin adduct capable of radionuclide ((68)Ga) uptake. This synthetic strategy offers a potentially general and convenient means of preparing targeted radiolabeling and radiotherapeutic agents.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biotin / chemistry*
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Chelating Agents / chemical synthesis*
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Chelating Agents / chemistry
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Cyclooctanes / chemical synthesis*
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Cyclooctanes / chemistry
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Heterocyclic Compounds, 1-Ring / chemistry*
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Molecular Structure
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Radiopharmaceuticals / chemical synthesis*
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Radiopharmaceuticals / chemistry
Substances
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Chelating Agents
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Cyclooctanes
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Heterocyclic Compounds, 1-Ring
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Radiopharmaceuticals
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1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
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Biotin