False susceptibility to amikacin by VITEK 2 in Acinetobacter baumannii harboring armA

Sunkyung Jung; Jin Kyung Yu; Sang Hyun Shin; Kang Gyun Park; Dong Wook Jekarl; Kyungja Han; Yeon-Joon Park

False susceptibility to amikacin by VITEK 2 in Acinetobacter baumannii harboring armA

Ann Clin Lab Sci. 2010 Spring;40(2):167-71.

Authors

Sunkyung Jung¹, Jin Kyung Yu, Sang Hyun Shin, Kang Gyun Park, Dong Wook Jekarl, Kyungja Han, Yeon-Joon Park

Affiliation

¹ Laboratory Medicine Department, St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.

PMID: 20421629

Abstract

Amikacin (AN) is the most active aminoglycoside for the treatment of infections caused by Acinetobacter baumannii. The VITEK 2 automated system showed false susceptibility to AN for the A. baumannii isolate harboring armA. This phenomenon was not observed in the Serratia marcescens isolate harboring armA, but was detected in its transconjugant E. coli J53.

MeSH terms

Acinetobacter baumannii / drug effects*
Acinetobacter baumannii / enzymology*
Acinetobacter baumannii / genetics
Acinetobacter baumannii / isolation & purification
Amikacin / pharmacology*
Carbonyl Cyanide m-Chlorophenyl Hydrazone / pharmacology
Disk Diffusion Antimicrobial Tests
Drug Resistance, Bacterial / drug effects*
Electrophoresis, Gel, Pulsed-Field
Genes, Bacterial / genetics*
Microbial Sensitivity Tests / methods*

Substances

Carbonyl Cyanide m-Chlorophenyl Hydrazone
Amikacin