Clostridium difficile toxinotype XI (A-B-) exhibits unique arrangement of PaLoc and its upstream region

Barbara Geric Stare; Maja Rupnik

doi:10.1016/j.anaerobe.2010.04.001

Clostridium difficile toxinotype XI (A-B-) exhibits unique arrangement of PaLoc and its upstream region

Anaerobe. 2010 Aug;16(4):393-5. doi: 10.1016/j.anaerobe.2010.04.001. Epub 2010 Apr 20.

Authors

Barbara Geric Stare¹, Maja Rupnik

Affiliation

¹ Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, Ljubljana, Slovenia. barbara.geric@guest.arnes.si

PMID: 20412866
DOI: 10.1016/j.anaerobe.2010.04.001

Abstract

Clostridium difficile toxinotype XI strains do not produce toxins A (TcdA) or B (TcdB) but do possess a nonfunctional remnant of the pathogenicity locus (PaLoc), bearing part of the sequence for tcdA. This is the first report of a type with absent upstream terminal PaLoc sequences and major genetic rearrangements of the PaLoc region.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Toxins / genetics*
Clostridioides difficile / genetics*
Enterotoxins / genetics
Gene Order*
Genetic Loci*

Substances

Bacterial Toxins
Enterotoxins
tcdA protein, Clostridium difficile