Cytotoxic nor-chamigrane and chamigrane endoperoxides from a basidiomycetous fungus

Supichar Chokpaiboon; Damrong Sommit; Thapong Teerawatananond; Nongnuj Muangsin; Taridaporn Bunyapaiboonsri; Khanitha Pudhom

doi:10.1021/np100103j

Cytotoxic nor-chamigrane and chamigrane endoperoxides from a basidiomycetous fungus

J Nat Prod. 2010 May 28;73(5):1005-7. doi: 10.1021/np100103j.

Authors

Supichar Chokpaiboon¹, Damrong Sommit, Thapong Teerawatananond, Nongnuj Muangsin, Taridaporn Bunyapaiboonsri, Khanitha Pudhom

Affiliation

¹ Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.

PMID: 20411928
DOI: 10.1021/np100103j

Abstract

A new nor-chamigrane endoperoxide, merulin A (1), and two new chamigrane endoperoxides, merulins B and C (2, 3), were isolated from the culture broth extract of an endophytic fungus of Xylocarpus granatum. Their structures were elucidated on the basis of spectroscopic, mainly NMR and MS, data. X-ray crystallographic analysis confirmed the structure of 1. Compounds 1 and 3 displayed significant cytotoxicity against human breast (BT474) and colon (SW620) cancer cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology*
Basidiomycota / chemistry*
Breast Neoplasms / drug therapy
Crystallography, X-Ray
Drug Screening Assays, Antitumor
Female
Humans
Molecular Conformation
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Peroxides / chemistry
Peroxides / isolation & purification*
Peroxides / pharmacology*

Substances

Antineoplastic Agents
Peroxides
merulin A
merulin B
merulin C