Bioactive constituents from chinese natural medicines. XXXVI. Four new acylated phenylethanoid oligoglycosides, kankanosides J1, J2, K1, and K2, from stems of Cistanche tubulosa

Chem Pharm Bull (Tokyo). 2010 Apr;58(4):575-8. doi: 10.1248/cpb.58.575.

Abstract

Four new acylated phenylethanoid oligoglycosides, kankanosides J(1) (1), J(2) (2), K(1) (3), and K(2) (4), were isolated from stems of Cistanche tubulosa (Orobanchaceae) together with isocampneoside I (5). Their structures were elucidated on the basis of chemical and physicochemical evidence. Among them, 3-5 were found to inhibit D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cells, Cultured
  • Cistanche / chemistry*
  • Drugs, Chinese Herbal / chemistry*
  • Galactosamine / metabolism
  • Glycosides / chemistry*
  • Glycosides / isolation & purification
  • Glycosides / pharmacology*
  • Hepatocytes / drug effects
  • Hepatocytes / metabolism
  • Mice
  • Molecular Structure
  • Plant Stems / chemistry*

Substances

  • Drugs, Chinese Herbal
  • Glycosides
  • kankanoside
  • Galactosamine