Elucidation of the structure and intermolecular interactions of a reversible cyclic-peptide inhibitor of the proteasome by NMR spectroscopy and molecular modeling

Angew Chem Int Ed Engl. 2010 May 25;49(23):3934-8. doi: 10.1002/anie.201000140.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Binding Sites
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology
  • Magnetic Resonance Spectroscopy*
  • Models, Molecular*
  • Peptides, Cyclic / chemistry*
  • Peptides, Cyclic / pharmacology
  • Proteasome Endopeptidase Complex / chemistry*
  • Proteasome Endopeptidase Complex / metabolism
  • Protein Binding
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Peptides, Cyclic
  • argyrin A
  • Proteasome Endopeptidase Complex