Pyrimidine-purine and pyrimidine heterodinucleosides synthesis containing a triazole linkage

R Lucas; P H Elchinger; P A Faugeras; R Zerrouki

doi:10.1080/15257771003708579

Pyrimidine-purine and pyrimidine heterodinucleosides synthesis containing a triazole linkage

Nucleosides Nucleotides Nucleic Acids. 2010 Mar;29(3):168-77. doi: 10.1080/15257771003708579.

Authors

R Lucas¹, P H Elchinger, P A Faugeras, R Zerrouki

Affiliation

¹ Faculte des Sciences et Techniques, Universite de Limoges, Laboratoire de Chimie des Substances Naturelles, Limoges, France.

PMID: 20408048
DOI: 10.1080/15257771003708579

Abstract

This article describes a synthetic route to generate two purine-pyrimidine and pyrimidine heterodinucleosides. Both microwave activated regioselective alkylation using hydride and copper-catalyzed-azide-alkyne-cycloaddition (CuAAC) were used in order to perform the synthesis.

MeSH terms

Catalysis
Copper / chemistry
Cyclization
Nucleic Acid Conformation
Oligonucleotides / chemical synthesis*
Oligonucleotides / chemistry*
Purines / chemistry*
Pyrimidines / chemistry*
Triazoles / chemistry*

Substances

Oligonucleotides
Purines
Pyrimidines
Triazoles
Copper
pyrimidine
purine