This chapter gives an educational overview of: * The origins and evolution of bioinformatics from its beginning where it was a discipline mainly oriented towards the resolution of problems in biology to the present where it shows a clear interest on the field of translational research in medicine. * The different aspects of bioinformatics, ranging from its application for the study of individual entities, such as a gene or a protein, through its role as support to the large sequencing projects, and the global approach to genomics to systems biology. * Bioinformatics resources most used by researchers, distinguishing between the different information resources (databases) and the tools (programs) used to process them. * The current relevance of bioinformatics in medicine, both in the field of biomedical research and in the fields of clinical practice and public health as well as its multiple connections with the field of medical informatics. * The main lines for research and development in translational medicine, its main applications in the field of genomics medicine and future challenges raised by the new trends in medicine.