DNA gyrase and topoisomerase IV are dual targets of zabofloxacin in Streptococcus pneumoniae

Int J Antimicrob Agents. 2010 Jul;36(1):97-8. doi: 10.1016/j.ijantimicag.2010.02.022. Epub 2010 Apr 18.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Substitution / genetics
  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / antagonists & inhibitors*
  • Bacterial Proteins / genetics
  • DNA Gyrase / genetics
  • DNA Topoisomerase IV / antagonists & inhibitors*
  • DNA Topoisomerase IV / genetics
  • Humans
  • Microbial Sensitivity Tests
  • Mutation, Missense
  • Streptococcus pneumoniae / drug effects*
  • Streptococcus pneumoniae / enzymology*
  • Topoisomerase II Inhibitors*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Topoisomerase II Inhibitors
  • DNA Topoisomerase IV
  • DNA Gyrase