Correction of endothelial dysfunction with impaza preparation in complex with enalapril and losartan during modeling of NO deficiency
Bull Exp Biol Med. 2009 Sep;148(3):511-3.
doi: 10.1007/s10517-010-0750-5.
[Article in
English,
Russian]
Affiliation
- 1 Kursk State Medical University, Federal Agency for Health Care and Social Development.
Abstract
Modeling of NO deficiency by administration of L-NAME to rats led to the development of arterial hypertension and endothelial dysfunction. Pronounced endothelium and cardioprotective effects of impaza under these experimental conditions manifested more markedly during combined administration of the preparation with standard hypotensive preparations enalapril and losartan.
MeSH terms
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Animals
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Antibodies / therapeutic use*
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Enalapril / therapeutic use*
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Hypertension / chemically induced
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Hypertension / drug therapy*
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Losartan / therapeutic use*
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Male
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NG-Nitroarginine Methyl Ester / pharmacology
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Nitric Oxide / deficiency*
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Rats
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Rats, Wistar
Substances
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Antibodies
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IMPAZA
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Nitric Oxide
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Enalapril
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Losartan
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NG-Nitroarginine Methyl Ester