Poly(amino acid)s micelle-mediated assembly of magnetite nanoparticles for ultra-sensitive long-term MR imaging of tumors

Chem Commun (Camb). 2010 May 28;46(20):3559-61. doi: 10.1039/b925106e. Epub 2010 Apr 15.

Abstract

Micelles composed of a novel weakly cationic poly(amino acid)s shell and clustered magnetite nanoparticles as a core were prepared and evaluated as a potent MR imaging contrast agent based on their superior physicochemical and magnetic properties and the effective MR imaging of cancer in vitro and in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids* / chemistry
  • Cations / chemistry
  • Colonic Neoplasms / diagnosis*
  • Contrast Media* / chemistry
  • Humans
  • Magnetic Resonance Imaging*
  • Magnetics*
  • Micelles
  • Nanoparticles / chemistry*
  • Particle Size
  • Polymers* / chemistry
  • Surface Properties

Substances

  • Amino Acids
  • Cations
  • Contrast Media
  • Micelles
  • Polymers