Synthesis of beta-hydroxyphosphonate and 1,2-dihydroxy acyclic nucleoside analogs via 1,3-dipolar cycloaddition strategy

M Ganesan; K M Muraleedharan

doi:10.1080/15257771003597709

Synthesis of beta-hydroxyphosphonate and 1,2-dihydroxy acyclic nucleoside analogs via 1,3-dipolar cycloaddition strategy

Nucleosides Nucleotides Nucleic Acids. 2010 Feb;29(2):91-6. doi: 10.1080/15257771003597709.

Authors

M Ganesan¹, K M Muraleedharan

Affiliation

¹ Department of Chemistry, Indian Institute of Technology Madras, Chennai, India.

PMID: 20391196
DOI: 10.1080/15257771003597709

Abstract

A convenient synthetic approach toward nucleoside analogs where beta-hydroxyphosphonate- or 1,2-dihydroxy units are connected to the nucleic acid base through a triazole spacer is discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chemistry, Organic / methods*
Crystallography, X-Ray
Cyclization
Nucleic Acid Conformation
Nucleosides / chemical synthesis*
Nucleosides / chemistry*
Organophosphonates / chemical synthesis*
Organophosphonates / chemistry
Propylene Glycols / chemical synthesis*
Propylene Glycols / chemistry
Purines / chemical synthesis*
Purines / chemistry
Pyrimidines / chemical synthesis*
Pyrimidines / chemistry
Triazoles / chemistry

Substances

Nucleosides
Organophosphonates
Propylene Glycols
Purines
Pyrimidines
Triazoles