This study examined differences in substance use and related risk factors in a matched sample of Hispanic and White non-Hispanic adolescents receiving brief alcohol counseling. Findings revealed that the White non-Hispanic adolescents reported smoking a higher number of cigarettes per day. The Hispanic adolescents reported perceiving less acceptance from the neighborhood environment in which they live, whereas their parents reported monitoring their teens less than the parents' of White non-Hispanic adolescents. Consistent with the findings found in community samples, the overall findings of this study suggest that Hispanic and White non-Hispanic adolescents enrolled in this alcohol intervention have similar baseline characteristics.