Synthesis and antitumor activity of bisindolylmaleimide and amino acid ester conjugates

J Asian Nat Prod Res. 2010 Jan;12(1):36-42. doi: 10.1080/10286020903413385.

Abstract

A series of novel bisindolylmaleimide and natural amino acid ester conjugates were synthesized and evaluated for their inhibitory activity against six tumor cell lines. Some compounds displayed interesting cytotoxic profiles. The most active compound 8e showed inhibitory activity against several human cancer cell lines.

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Drug Screening Assays, Antitumor
  • Esters
  • HCT116 Cells
  • HT29 Cells
  • Hep G2 Cells
  • Humans
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Indoles / pharmacology*
  • K562 Cells
  • Maleimides / chemical synthesis*
  • Maleimides / chemistry
  • Maleimides / pharmacology*
  • Molecular Structure
  • Staurosporine / chemistry

Substances

  • Antineoplastic Agents
  • Esters
  • Indoles
  • Maleimides
  • Staurosporine
  • bisindolylmaleimide