Design, synthesis, and complementary recognition of beta-hairpin peptides stabilized by artificial DNA base-pairing amino acids

Chem Commun (Camb). 2010 May 7;46(17):2947-9. doi: 10.1039/b924239b. Epub 2010 Mar 8.

Abstract

A novel DNA base-pairing beta-hairpin peptide involving intramolecular hydrogen bonds for induction of beta-hairpin secondary structure and intermolecular complementary hydrogen bonds between thymine and diaminopyridine for molecular recognition has been synthesized.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry*
  • Aminopyridines / chemistry
  • Base Pairing
  • DNA / chemistry*
  • Hydrogen Bonding
  • Peptide Nucleic Acids / chemistry
  • Peptides / chemical synthesis*
  • Peptides / chemistry
  • Protein Structure, Secondary
  • Thymine / chemistry

Substances

  • Amino Acids
  • Aminopyridines
  • Peptide Nucleic Acids
  • Peptides
  • DNA
  • Thymine