Secondary metabolites from the roots of Litsea hypophaea and their antitubercular activity

Pei-Chi Pan; Ming-Jen Cheng; Chien-Fang Peng; Hung-Yi Huang; Jih-Jung Chen; Ih-Sheng Chen

doi:10.1021/np100022s

Secondary metabolites from the roots of Litsea hypophaea and their antitubercular activity

J Nat Prod. 2010 May 28;73(5):890-6. doi: 10.1021/np100022s.

Authors

Pei-Chi Pan¹, Ming-Jen Cheng, Chien-Fang Peng, Hung-Yi Huang, Jih-Jung Chen, Ih-Sheng Chen

Affiliation

¹ Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China.

PMID: 20384293
DOI: 10.1021/np100022s

Abstract

Bioassay-guided fractionation of the roots of Litsea hypophaea led to the isolation of seven new butanolides, namely, litseakolides H-N (1-7), all with the 3R,4S configuration, as well as three new biarylpropanoids, hypophaone (8), hypophaol (9), and hypophane (10), and 15 known compounds. The structures of 1-10 were determined by means of spectroscopic analysis. Litseakolide L (5) and N-trans-feruloylmethoxytyramine (11) showed antitubercular activity against Mycobacterium tuberculosis strain H(37)Rv, with MIC values of 25 and 1.6 microg/mL, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

4-Butyrolactone / analogs & derivatives*
4-Butyrolactone / chemistry
4-Butyrolactone / isolation & purification*
4-Butyrolactone / pharmacology*
Antitubercular Agents / chemistry
Antitubercular Agents / isolation & purification*
Antitubercular Agents / pharmacology*
Litsea / chemistry*
Microbial Sensitivity Tests
Molecular Structure
Mycobacterium tuberculosis / drug effects*
Nuclear Magnetic Resonance, Biomolecular
Plant Roots / chemistry
Stereoisomerism
Taiwan

Substances

Antitubercular Agents
4-Butyrolactone