Potent inhibition of protein tyrosine phosphatase 1B by copper complexes: implications for copper toxicity in biological systems

Qingming Wang; Liping Lu; Caixia Yuan; Kai Pei; Zhiwei Liu; Maolin Guo; Miaoli Zhu

doi:10.1039/b925603b

Potent inhibition of protein tyrosine phosphatase 1B by copper complexes: implications for copper toxicity in biological systems

Chem Commun (Camb). 2010 May 28;46(20):3547-9. doi: 10.1039/b925603b. Epub 2010 Apr 9.

Authors

Qingming Wang¹, Liping Lu, Caixia Yuan, Kai Pei, Zhiwei Liu, Maolin Guo, Miaoli Zhu

Affiliation

¹ Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of the Education Ministry, Shanxi University, Taiyuan, Shanxi 030006, PR China.

PMID: 20383386
DOI: 10.1039/b925603b

Abstract

A new dinuclear copper complex and several Cu-amino acid complexes inhibit protein tyrosine phosphatase 1B competitively at submicromolar levels, suggesting that copper complexes may interfere with cellular signaling pathways by inhibiting protein tyrosine phosphatases.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acids / chemistry*
Cell Survival / drug effects
Copper / chemistry*
Crystallography, X-Ray
Dose-Response Relationship, Drug
Humans
Models, Molecular
Organometallic Compounds / chemistry
Organometallic Compounds / pharmacology*
Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors*
Protein Tyrosine Phosphatase, Non-Receptor Type 1 / metabolism
Signal Transduction / drug effects
Structure-Activity Relationship
T-Lymphocytes / drug effects*

Substances

Amino Acids
Organometallic Compounds
Copper
Protein Tyrosine Phosphatase, Non-Receptor Type 1