Click reaction synthesis of carbohydrate derivatives from ristocetin aglycon with antibacterial and antiviral activity

Gábor Pintér; Ilona Bereczki; Gyula Batta; Réka Otvös; Ferenc Sztaricskai; Erzsébet Roth; Eszter Ostorházi; Ferenc Rozgonyi; Lieve Naesens; Mariann Szarvas; Zoltán Boda; Pál Herczegh

doi:10.1016/j.bmcl.2010.03.080

Click reaction synthesis of carbohydrate derivatives from ristocetin aglycon with antibacterial and antiviral activity

Bioorg Med Chem Lett. 2010 May 1;20(9):2713-7. doi: 10.1016/j.bmcl.2010.03.080. Epub 2010 Mar 27.

Authors

Gábor Pintér¹, Ilona Bereczki, Gyula Batta, Réka Otvös, Ferenc Sztaricskai, Erzsébet Roth, Eszter Ostorházi, Ferenc Rozgonyi, Lieve Naesens, Mariann Szarvas, Zoltán Boda, Pál Herczegh

Affiliation

¹ Department of Pharmaceutical Chemistry, University of Debrecen, Egyetem tér 1, H-4010 Debrecen, Hungary.

PMID: 20381348
DOI: 10.1016/j.bmcl.2010.03.080

Abstract

New sugar derivatives of ristocetin were prepared by copper-catalyzed 1,3-dipolar cycloaddition reaction using azido-ristocetin aglycon and various propargyl glycosides. Some of them were found to be active against gram-positive bacteria and showed favorable antiviral activity against the H1N1 subtype of influenza A virus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Antiviral Agents / chemical synthesis*
Antiviral Agents / chemistry
Antiviral Agents / pharmacology
Catalysis
Copper / chemistry
Doxorubicin / analogs & derivatives*
Doxorubicin / chemistry
Humans
Influenza A Virus, H1N1 Subtype / drug effects
Microbial Sensitivity Tests
Ristocetin / analogs & derivatives*
Ristocetin / chemical synthesis
Ristocetin / pharmacology

Substances

Anti-Bacterial Agents
Antiviral Agents
ristocetin aglycon
Ristocetin
Copper
Doxorubicin