Efficient DNA photocleavage by [Ru(bpy)2(dppn)]2+ with visible light

Chem Commun (Camb). 2010 Apr 14;46(14):2426-8. doi: 10.1039/b925574e. Epub 2010 Jan 27.

Abstract

The population and reactivity of two low-lying excited states in [Ru(bpy)(2)(dppn)](2+) (bpy = 2,2'-bipyridine, dppn = benzo[i]dipyrido[3,2-a:2',3'-c]phenazine), a weakly emissive (3)MLCT state and a long-lived ligand-centered (3)pipi* state, lead to efficient photoinduced DNA damage. Irradiation with visible light results in nearly complete DNA cleavage within 30 s (lambda(irr) > or = 455 nm), likely from the combined action of guanine oxidation and the production of reactive oxygen species derived from (1)O(2).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Coordination Complexes / chemistry*
  • DNA / chemistry*
  • DNA / radiation effects
  • DNA Cleavage
  • Guanine / chemistry
  • Light*
  • Organometallic Compounds / chemistry*
  • Oxidation-Reduction
  • Photolysis
  • Reactive Oxygen Species / metabolism
  • Ruthenium / chemistry*

Substances

  • Coordination Complexes
  • Organometallic Compounds
  • Reactive Oxygen Species
  • Guanine
  • Ruthenium
  • DNA