A survey on the management of gout in Malaysia

Int J Rheum Dis. 2009 Dec;12(4):329-35. doi: 10.1111/j.1756-185X.2009.01431.x.

Abstract

Aim: The aim of this study was to ascertain the management of gout by doctors in Malaysia.

Methods: A cross-sectional questionnaire survey was carried out among doctors attending rheumatology post-graduate courses, where gout was not a lecture topic.

Results: A total of 128 questionnaires were analyzed, of which the majority (67: 52.3%) were general practitioners. In the treatment of acute gout, 68.0% use non-selective non-steroidal anti-inflammatory drugs (NSAIDs), 53.9% use selective COX-2 inhibitors (coxibs), 66.4% use colchicine and 10.2% use allopurinol (ALLO). In the treatment of chronic gout, 36.7% use NSAIDs, 44.5% use coxibs, 19.5% use colchicine and 93% use ALLO. In both acute and chronic gout, corticosteroids (CS) are not used by over 90% of respondents. Fifty percent would stop ALLO during an acute attack. 95.3% do not start ALLO during an acute attack; 87.5% would start ALLO after the attack, with a median of 14 days afterwards. Once ALLO was started, 54.7% would continue indefinitely. Regarding target urate levels while on treatment, 10.9% would be satisfied with a high normal range, 21.9% middle of the range, 18.0% low normal range and 45.3% anywhere within the normal range. Fifteen percent would treat asymptomatic hyperuricemia.

Conclusions: In Malaysia, anti-inflammatory agents are most commonly used for the treatment of acute and chronic gout, with corticosteroid usage at a low level. However, there are areas of concern regarding the diagnosis of gout and the usage of ALLO which are not consistent with current guidelines.

MeSH terms

  • Acute Disease
  • Allopurinol / therapeutic use
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Chronic Disease
  • Colchicine / therapeutic use
  • Cross-Sectional Studies
  • Cyclooxygenase 2 Inhibitors / therapeutic use
  • Glucocorticoids / therapeutic use
  • Gout / diagnosis
  • Gout / drug therapy*
  • Gout / physiopathology
  • Gout Suppressants / therapeutic use*
  • Humans
  • Malaysia
  • Primary Health Care* / statistics & numerical data
  • Professional Practice* / statistics & numerical data
  • Reference Values
  • Surveys and Questionnaires
  • Uric Acid / blood

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Cyclooxygenase 2 Inhibitors
  • Glucocorticoids
  • Gout Suppressants
  • Uric Acid
  • Allopurinol
  • Colchicine