Helicobacter pylori infection is associated with an increased risk for development of duodenal ulcers, gastric ulcers, gastric adenocarcinomas and gastric lymphomas. However, resistant strains have developed because of antibiotic treatment. In this study, the water, acetone, chloroform and methanol extracts of two Solancaceae plants, Solanum erianthum and Solanum torvum (ST), were tested for their anti-H. pylori activity. All of ST extracts were able to inhibit the growth of H. pylori and showed better activities against antibiotic strains than the reference strain. Among them, chloroform extract of ST (ST-C) possessed the strongest ability to inhibit H. pylori growth. Association assay was performed by the ST-C showing that ST-C was able to interrupt the association of bacteria to host cells. Furthermore, H. pylori-induced apoptosis could also be efficiently suppressed by the ST-C. It was able to interfere with the interaction between bacteria and host cells and also target H. pylori-induced gastric injury by suppressing apoptosis. Therefore, ST-C may offer a new approach for the treatment of H. pylori. Further studies on the elucidation of the molecular mechanisms of the growth inhibition on H. pylori by ST-C, and to identify active compounds in the plants are in progress.