A case of rapid progression and vision loss in a patient with primary intraocular lymphoma

Ocul Immunol Inflamm. 2010 Apr;18(2):99-100. doi: 10.3109/09273940903370748.

Abstract

Purpose: To describe an atypical case of primary intraocular lymphoma (PIOL) with rapid progression leading to vision loss and death.

Methods: A 71-year-old woman with a history of PIOL presented with a sudden decline in vision. MRI, CSF cytology, and ocular examination 2 months prior were unremarkable.

Results: Repeat MRI of the brain and orbits at this time revealed a 0.8 x 2.4-cm lesion of the left choroid plexus. LP revealed rare atypical B cells. The patient rapidly deteriorated and died a month later.

Conclusion: Recognition of the potential for rapid progression and mortality in patients with PIOL is essential.

Publication types

  • Case Reports
  • Research Support, N.I.H., Intramural

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Blindness / diagnosis*
  • Blindness / drug therapy
  • Blindness / etiology
  • Disease Progression
  • Eye Neoplasms / complications*
  • Eye Neoplasms / diagnosis
  • Eye Neoplasms / drug therapy
  • Fatal Outcome
  • Female
  • Humans
  • Lymphoma, B-Cell / complications*
  • Lymphoma, B-Cell / diagnosis
  • Lymphoma, B-Cell / drug therapy
  • Magnetic Resonance Imaging
  • Methotrexate / administration & dosage
  • Procarbazine / administration & dosage
  • Vincristine / administration & dosage

Substances

  • Procarbazine
  • Vincristine
  • Methotrexate