Abstract
A new chemo-enzymatic route to both isomers of 2-hydroxy-4-phenylbutyric acid is reported. The key step is the lactonase-catalyzed hydrolysis of cis- and trans-2-hydroxy-4-phenyl-4-butyrolactones followed by hydrogenation over Pd/C to afford optically pure 2-hydroxy-4-phenylbutyric acid.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carbon / chemistry*
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Carboxylic Ester Hydrolases / chemistry*
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Catalysis
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Hydrogenation
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Molecular Structure
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Palladium / chemistry*
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Phenylbutyrates / chemical synthesis
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Phenylbutyrates / chemistry*
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Stereoisomerism
Substances
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Phenylbutyrates
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2-hydroxy-4-phenylbutyric acid
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Palladium
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Carbon
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Carboxylic Ester Hydrolases
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delta-lactonase