Abstract
A mitochondria-targeted chimeric compound consisting of a rhodamine derivative linked to a plastoquinone molecule (10-(6'-plastoquinonyl)decylrhodamine, SkQR1) was studied under conditions of acute brain or kidney damage. A protective effect of this compound was demonstrated in a model of focal brain ischemia, rat kidney ischemia/reperfusion, myoglobinuria (rhabdomyolysis, or crush syndrome), and pyelonephritis. We found that a single intraperitoneal injection of SkQR1 diminishes the size of the ischemic zone in the brain and improves performance of a test characterizing neurological deficit in ischemic animals. Control substance not containing plastoquinone appeared to be not neuroprotective. The data show that SkQR1 is a nephroprotectant and neuroprotectant, which can be due to the antioxidative action of this Skulachev cation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain Ischemia / metabolism
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Brain Ischemia / physiopathology
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Intracellular Space / drug effects
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Intracellular Space / metabolism
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Kidney / drug effects*
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Kidney / metabolism
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Kidney / pathology
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Kidney / physiopathology
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Male
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Mitochondria / drug effects
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Mitochondria / metabolism
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Myoglobinuria / metabolism
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Myoglobinuria / physiopathology
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Nervous System Diseases / complications
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Nervous System Diseases / metabolism
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Nervous System Diseases / physiopathology
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Neuroprotective Agents / pharmacology*
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Oxidative Stress / drug effects
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Plastoquinone / analogs & derivatives*
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Plastoquinone / pharmacology
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Pyelonephritis / metabolism
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Pyelonephritis / physiopathology
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Rats
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Reactive Oxygen Species / metabolism
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Reperfusion Injury / complications
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Reperfusion Injury / metabolism
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Reperfusion Injury / physiopathology
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Rhodamines / pharmacology*
Substances
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10-(6'-plastoquinonyl) decylrhodamine 19
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Neuroprotective Agents
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Reactive Oxygen Species
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Rhodamines
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Plastoquinone