Isolation and structure elucidation of an interaction product of aminotadalafil found in an illegal health food product

Adrian Häberli; Philippe Girard; Min-Yong Low; Xiaowei Ge

doi:10.1016/j.jpba.2010.03.008

Isolation and structure elucidation of an interaction product of aminotadalafil found in an illegal health food product

J Pharm Biomed Anal. 2010 Sep 21;53(1):24-8. doi: 10.1016/j.jpba.2010.03.008. Epub 2010 Mar 11.

Authors

Adrian Häberli¹, Philippe Girard, Min-Yong Low, Xiaowei Ge

Affiliation

¹ Official Medicines Control Laboratory, Swissmedic, Hallerstrasse 7, CH-3000 Berne 9, Switzerland.

PMID: 20363087
DOI: 10.1016/j.jpba.2010.03.008

Abstract

An interaction product of aminotadalafil was isolated from an illegal health food product. The structure of the interaction product was elucidated by means of IR, NMR, and mass spectroscopy. The hitherto unknown compound was characterized as condensation product of aminotadalafil and hydroxymethylfuraldehyde and is probably the result of a drug-excipient incompatibility.

MeSH terms

Benzodioxoles / chemistry*
Carbolines / chemistry*
Drug Contamination*
Drug Incompatibility*
Food, Organic / analysis*
Furaldehyde / analogs & derivatives
Furaldehyde / chemistry
Furaldehyde / isolation & purification*
Magnetic Resonance Spectroscopy / methods
Mass Spectrometry / methods
Molecular Structure
Spectrophotometry, Infrared

Substances

Benzodioxoles
Carbolines
Furaldehyde
aminotadalafil