Synthesis, structures, and urease inhibitory activities of three copper(II) and zinc(II) complexes with 2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol

Zhong-Lu You; Li-Li Ni; Da-Hua Shi; Shun Bai

doi:10.1016/j.ejmech.2010.03.012

Synthesis, structures, and urease inhibitory activities of three copper(II) and zinc(II) complexes with 2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol

Eur J Med Chem. 2010 Jul;45(7):3196-9. doi: 10.1016/j.ejmech.2010.03.012. Epub 2010 Mar 16.

Authors

Zhong-Lu You¹, Li-Li Ni, Da-Hua Shi, Shun Bai

Affiliation

¹ Department of Chemistry and Chemical Engineering, Liaoning Normal University, Huanghe Road 850, Dalian 116029, PR China. youzhonglu@yahoo.com.cn

PMID: 20362357
DOI: 10.1016/j.ejmech.2010.03.012

Abstract

In order to explore novel urease inhibitors, three new mononuclear complexes of Cu(II) and Zn(II) with Schiff base 2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol have been prepared and structurally characterized by X-ray crystallography. Among the three complexes, two Cu(II) complexes show strong urease inhibitory activities with the IC(50) values being much lower than that of the acetohydroxamic acid, while the Zn(II) complex shows no activity at the concentration of 100 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Copper / chemistry*
Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology
Fabaceae / enzymology
Nitrophenols / chemistry*
Organometallic Compounds / chemical synthesis
Organometallic Compounds / chemistry*
Organometallic Compounds / pharmacology*
Urease / antagonists & inhibitors*
Zinc / chemistry*

Substances

2-((2-(2-hydroxyethylamino)ethylimino)methyl)-4-nitrophenol
Enzyme Inhibitors
Nitrophenols
Organometallic Compounds
Copper
Urease
Zinc