Chlorin e6-cholesterol conjugate and its copper complex. Simple synthesis and entrapping in phospholipid vesicles

Irina A Nikolaeva; Alexander Yu Misharin; Gelii V Ponomarev; Vladimir P Timofeev; Yaroslav V Tkachev

doi:10.1016/j.bmcl.2010.03.041

Chlorin e6-cholesterol conjugate and its copper complex. Simple synthesis and entrapping in phospholipid vesicles

Bioorg Med Chem Lett. 2010 May 1;20(9):2872-5. doi: 10.1016/j.bmcl.2010.03.041. Epub 2010 Mar 11.

Authors

Irina A Nikolaeva¹, Alexander Yu Misharin, Gelii V Ponomarev, Vladimir P Timofeev, Yaroslav V Tkachev

Affiliation

¹ V.N. Orekhovich Institute of Biomedical Chemistry RAMS, Moscow, Russia.

PMID: 20356740
DOI: 10.1016/j.bmcl.2010.03.041

Abstract

Synthesis of 13'[(cholest-5-en)-3beta-yloxyethoxycarbamoyl]-chlorin e6 starting from methylpheophorbide and 3beta(2-hydroxy)-ethoxycholest-5-ene is presented, as well as the preparation of related copper complex. Both conjugates obtained may be simply incorporated in phosphatidyl choline vesicles.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chlorophyllides
Cholesterol / chemistry*
Coordination Complexes / chemical synthesis*
Coordination Complexes / chemistry
Coordination Complexes / pharmacology
Copper / chemistry*
Electron Spin Resonance Spectroscopy
Lipid Bilayers / chemistry
Lipid Bilayers / metabolism
Photosensitizing Agents / chemical synthesis*
Photosensitizing Agents / chemistry
Photosensitizing Agents / pharmacology
Porphyrins / chemistry*

Substances

Chlorophyllides
Coordination Complexes
Lipid Bilayers
Photosensitizing Agents
Porphyrins
phytochlorin
Copper
Cholesterol