D225G mutation in the hemagglutinin protein found in 3 severe cases of 2009 pandemic influenza A (H1N1) in Spain

Diagn Microbiol Infect Dis. 2010 Jun;67(2):207-8. doi: 10.1016/j.diagmicrobio.2010.02.002. Epub 2010 Mar 31.

Abstract

From 27 April to 16 December 2009, we analyzed the hemagglutinin gene sequence of 2009 pandemic influenza A (H1N1) virus in 189 respiratory specimens. We only found the D225G mutation in 3 severe cases. However, it was not found in samples from other cases with or without clinical criteria of severity. The biologic significance of this mutation remains still unclear.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Hemagglutinins, Viral / genetics*
  • Hemagglutinins, Viral / isolation & purification
  • Humans
  • Influenza A Virus, H1N1 Subtype / genetics*
  • Influenza A Virus, H1N1 Subtype / isolation & purification
  • Influenza, Human / virology*
  • Mutation, Missense*
  • Point Mutation*
  • Sequence Analysis, DNA
  • Spain

Substances

  • Hemagglutinins, Viral
  • hemagglutinin fusogenic peptide, influenza virus