Novel benzimidazole-pyrimidine conjugates as potent antitumor agents

Heba T Abdel-Mohsen; Fatma A F Ragab; Mostafa M Ramla; Hoda I El Diwani

doi:10.1016/j.ejmech.2010.02.011

Novel benzimidazole-pyrimidine conjugates as potent antitumor agents

Eur J Med Chem. 2010 Jun;45(6):2336-44. doi: 10.1016/j.ejmech.2010.02.011. Epub 2010 Feb 13.

Authors

Heba T Abdel-Mohsen¹, Fatma A F Ragab, Mostafa M Ramla, Hoda I El Diwani

Affiliation

¹ Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical and Drug Industries Research, National Research Centre, Cairo, Egypt.

PMID: 20356655
DOI: 10.1016/j.ejmech.2010.02.011

Abstract

As a continuation to our previous work in synthesizing antitumor benzimidazoles, a series of 2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-(substituted)-6-phenylpyrimidine-5-carbonitriles was synthesized. Evaluation of the synthesized compounds for their in vitro cytotoxic activity against twelve cell lines namely, Cervical carcinoma (KB), Ovarial carcinoma (SK OV-3), CNS cancer (SF-268), Non small lung cancer (NCI H460), Colonadenocarcinoma (RKOP27), Leukaemia (HL60, U937, K562), Melanoma (G361, SK-MEL-28) and Neuroblastoma (GOTO, NB-1) revealed their marked potency when compared with known anticancer drugs.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology*
Benzimidazoles / chemistry*
Cell Line, Tumor
Cell Proliferation / drug effects
Humans
Lethal Dose 50
Pyrimidines / chemistry*

Substances

Antineoplastic Agents
Benzimidazoles
Pyrimidines
benzimidazole
pyrimidine