Abstract
New acyclovir esters with peptidomimetics were synthesized and evaluated in vitro for their antiviral activity against the replication of Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2). The influence of peptidomimetics containing oxazole and thiazolyl-thiazole moieties on the antiviral activity is also reported. The esters were synthesized using the coupling reagents N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) and N,N-dimethyl-4-aminopyridine (DMAP) as a catalyst.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acyclovir / analogs & derivatives*
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Acyclovir / chemical synthesis
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Acyclovir / pharmacology
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology
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Carbodiimides
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Esters
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Herpesvirus 1, Human / drug effects*
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Herpesvirus 1, Human / growth & development
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Pyridines
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Virus Replication / drug effects
Substances
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1-ethyl-3-(3-(diethylamino)propyl)carbodiimide
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4-(dimethylamine)pyridine
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Antiviral Agents
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Carbodiimides
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Esters
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Pyridines
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Acyclovir