New analogues of acyclovir--synthesis and biological activity

Z Naturforsch C J Biosci. 2010 Jan-Feb;65(1-2):29-33. doi: 10.1515/znc-2010-1-205.

Abstract

New acyclovir esters with peptidomimetics were synthesized and evaluated in vitro for their antiviral activity against the replication of Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2). The influence of peptidomimetics containing oxazole and thiazolyl-thiazole moieties on the antiviral activity is also reported. The esters were synthesized using the coupling reagents N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) and N,N-dimethyl-4-aminopyridine (DMAP) as a catalyst.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyclovir / analogs & derivatives*
  • Acyclovir / chemical synthesis
  • Acyclovir / pharmacology
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / pharmacology
  • Carbodiimides
  • Esters
  • Herpesvirus 1, Human / drug effects*
  • Herpesvirus 1, Human / growth & development
  • Pyridines
  • Virus Replication / drug effects

Substances

  • 1-ethyl-3-(3-(diethylamino)propyl)carbodiimide
  • 4-(dimethylamine)pyridine
  • Antiviral Agents
  • Carbodiimides
  • Esters
  • Pyridines
  • Acyclovir