Multifaceted role of heat shock protein 70 in neurons

Mol Neurobiol. 2010 Oct;42(2):114-23. doi: 10.1007/s12035-010-8116-6. Epub 2010 Apr 1.

Abstract

Heat shock protein 70 (Hsp70) plays important roles in neural protection from stress by assisting cellular protein folding. In this review we discuss the current understanding of inducible and constitutive Hsp70 in maintaining and protecting neuronal synaptic function under normal and stressed conditions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytoprotection
  • HSP70 Heat-Shock Proteins / chemistry
  • HSP70 Heat-Shock Proteins / metabolism*
  • Humans
  • Neurons / cytology
  • Neurons / metabolism*
  • Neurotransmitter Agents / metabolism
  • Stress, Physiological
  • Synapses / metabolism
  • Synapses / pathology

Substances

  • HSP70 Heat-Shock Proteins
  • Neurotransmitter Agents