Polyaxibetaine, an amino acid derivative from the marine sponge Axinella polypoides

Anna Aiello; Ernesto Fattorusso; Paolo Luciano; Marialuisa Menna; Rocco Vitalone

doi:10.1021/np900759n

Polyaxibetaine, an amino acid derivative from the marine sponge Axinella polypoides

J Nat Prod. 2010 Apr 23;73(4):620-2. doi: 10.1021/np900759n.

Authors

Anna Aiello¹, Ernesto Fattorusso, Paolo Luciano, Marialuisa Menna, Rocco Vitalone

Affiliation

¹ Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131, Napoli, Italy.

PMID: 20353167
DOI: 10.1021/np900759n

Abstract

A new pyridinium derivative, polyaxibetaine (3), has been isolated from the marine sponge Axinella polypoides, together with two known modified amino acids, 1 and 2. The planar structure of compound 3 has been elucidated by spectroscopic methods; definition of the absolute configuration of compounds 1-3 has been carried out through ECD studies.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acids / chemistry
Amino Acids / isolation & purification
Animals
Axinella / chemistry*
Marine Biology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pyridinium Compounds / chemistry
Pyridinium Compounds / isolation & purification*

Substances

Amino Acids
Pyridinium Compounds
axiphenylalaninium
axityrosinium
polyaxibetaine