Coronary stents are playing an effective way of curing cardiovascular diseases while a major drawback of restenosis is in general still present. Restenosis is resulting from neointimal hyperplasia and thrombosis which induced by the vascular lesion, hemodynamic modification and the reduction or oscillation of wall shear stress (WSS). The crucial factors that would determine the restenosis were reviewed in this paper, including the material bio-compatibilities, surface treatments, stent configuration designs and hemodynamics analyses. In particular, the hemodynamics after stents implantation based on in vivo, in vitro or Computational Fluid Dynamics (CFD) methods was discussed. A novel CFD and experimental approach of dynamics in the stent-vascular coupling system was proposed.