Variable transcription factor binding: a mechanism of evolutionary change

Patricia J Wittkopp

doi:10.1371/journal.pbio.1000342

Variable transcription factor binding: a mechanism of evolutionary change

PLoS Biol. 2010 Mar 23;8(3):e1000342. doi: 10.1371/journal.pbio.1000342.

Author

Patricia J Wittkopp¹

Affiliation

¹ Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America. wittkopp@umich.edu

Abstract

This primer discusses a study from Bradley et al. in which changes in transcription factor binding between two Drosophila species are revealed by chromatin immunoprecipitation and high-throughput sequencing.

MeSH terms

Animals
Binding Sites
Biological Evolution*
DNA* / genetics
DNA* / metabolism
Gene Expression Regulation
Genome
Protein Binding
Transcription Factors / genetics
Transcription Factors / metabolism*

Substances

Transcription Factors
DNA