In a survey of mycotic human skin and nail lesions in Chiriquí, Western Panama, Talaromyces indigoticus was isolated in one case. This ascomycete is characterised by formation of gymnothecia containing oval, spinose and yellow ascospores, which become blue in mounting fluids, and by short monoverticillate or biverticillate penicilli. It is here reported the first time for Panama and the American continent. Because the strain was isolated from an onychomycosis together with a dermatophyte and other fungal strains, the pathological impact of Talaromyces indigoticus is not evident.